ML-20
ML-20, Malabaricone C (HY-N8518) analogue, is a autophagy inhibitor and radiosensitizer. ML-20 inhibits cell growth, induces cell apoptosis . ML-20 induces DNA double-strand breaks, loss of mitochondrial membrane potential (MMP), and lysosomal membrane permeabilization (LMP) . ML-20 induces endoplasmic reticulum stress and concurrent inhibition of autophagy flux due to LMP [1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Autophagy
Related Pathways
Apoptosis; Autophagy
Applications
COVID-19-immunoregulation
Field of Research
Cancer
Smiles
OC1=CC=C(C=C1O)CCCCCCCCCC2=C(C=CC=C2O)O
Molecular Formula
C21H28O4
Molecular Weight
344.44
References & Citations
[1]Kundu K, et al. Synthesis, Structure-Activity Relationship, and Biological Evaluation of a Novel Malabaricone Derivative: A Potent Anticancer Agent and Radiosensitizer That Targets Autophagy Flux. ACS Omega. 2025 May 21;10 (21) :21589-21608.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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