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JAK2-IN-12

JAK2-IN-12 (compound 23) is a JAK2 inhibitor with a pIC50 of 8.2. JAK2-IN-12 can be used for study of myelofibrosi[1].

Product Specifications

UNSPSC

12352005

Target

JAK

Related Pathways

Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Field of Research

Cancer

Smiles

CC1=C(C2=CC(COC/C=C/COCC3=C(OCCN4CCCC4)C=CC5=C3)=CC=C2)N=C(N5)N=C1

Molecular Formula

C29H34N4O3

Molecular Weight

486.61

References & Citations

[1]Braz NF, et al. Application of Free Energy Perturbation (FEP) Methodology for Predicting the Binding Affinity of Macrocyclic JAK2 Inhibitor Analogues of Pacritinib. ACS Med Chem Lett. 2025 May 21;16 (6) :1066-1072.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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