BRD4/FKBP12 degrader-1
BRD4/FKBP12 degrader-1 (a1d) is a BRD4/FKBP12 degrader with anti-cancer activity (BRD4 ligand: HY-78695, FKBP12 ligand: HY-176501, linker: HY-140212) [1].
Product Specifications
UNSPSC
12352005
Target
Epigenetic Reader Domain; FKBP
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(NCCOCCN1C=C(COC[C@@H]2CN(C([C@H]3N(S(C4=CC(Cl)=CC(Cl)=C4)(=O)=O)[C@@H]2CCC3)=O)CC5=NC=CC=C5)N=N1)C[C@@H]6N=C(C7=CC=C(Cl)C=C7)C8=C(SC(C)=C8C)N9C6=NN=C9C
Molecular Formula
C47H50Cl3N11O6S2
Molecular Weight
1035.46
References & Citations
[1]Ahmed Bulldan, et al. Heterobifunctional Protein Binders Enable Cell Type-Specific Killing Through In-cell Enrichment. Posted May 17, 2025.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
FKBP12
Curated Selection
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