ST-899

ST-899 is a novel platelet-activating factor (PAF) receptor antagonist. ST-899 can significantly reduce the mortality of mice with endotoxin (LPS) -induced shock. ST-899 can significantly inhibit the increase in serum tumor necrosis factor (TNF) levels induced by LPS, but has no effect on interleukin-6 (IL-6) . The regulatory mechanism of ST-899 is to block the positive feedback loop between PAF and TNF, thereby reducing the inflammatory response. ST-899 can be used to study inflammatory diseases such as septic shock[1].

Product Specifications

CAS Number

[143484-41-7]

UNSPSC

12352005

Target

Platelet-activating Factor Receptor (PAFR) ; TNF Receptor

Related Pathways

Apoptosis; GPCR/G Protein

Field of Research

Inflammation/Immunology

Smiles

O=C(O/1)C2=CC=C(Cl)C=C2C1=C\COC(C[C@@H](OC(CC(C)C)=O)C[N+](C)(C)C)=O.[Br-]

Molecular Formula

C22H29BrClNO6

Molecular Weight

518.83

References & Citations

[1]Ruggiero V, et al. Beneficial effects of a novel platelet-activating factor receptor antagonist, ST 899, on endotoxin-induced shock in mice. Shock. 1994 Oct;2 (4) :275-80.