Pro-Dasatinib
Pro-Dasatinib (compound 2j), an amino acid analog of Dasatinib (HY-10181), is a potent Src/Abl kinase inhibitor. Pro-Dasatinib has antiproliferative activity against K652 leukemia cancer cells with an IC50 of 0.21 nM.
Product Specifications
CAS Number
[2468065-01-0]
UNSPSC
12352005
Target
Bcr-Abl; Src
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Purity
98.06
Smiles
O=C([C@@H]1CCCN1)N(CC2)CCN2C3=NC(C)=NC(NC4=NC=C(C(NC5=C(C=CC=C5Cl)C)=O)S4)=C3
Molecular Formula
C25H29ClN8O2S
Molecular Weight
541.07
References & Citations
[1]Buchappa, G.et al. (2016) . Design and Synthesis of Novel Dasatinib Analogues. Asian Journal of Chemistry, 28 (6), 1275-1280.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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