ADC-5 drug-linker

ADC-5 drug-linker (Compound linker-payload 5) is a drug-linker conjugate for ADC with potent anti-tumor activity. ADC-5 drug-linker can be used to synthesize NLRP3 agonist 3 (HY-176452) [1].

Product Specifications

UNSPSC

12352005

Target

Drug-Linker Conjugates for ADC

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

NC1=NC2=CC(C3=CC=NN3)=CC=C2C(N[C@H]4CC[C@H](OC([C@@H](NC([C@@H](NC(CCOCCOCCOCCOCCN(C(C=C5)=O)C5=O)=O)C(C)C)=O)CCCNC(N)=O)=O)C4)=C1

Molecular Formula

C43H60N10O11

Molecular Weight

893.00

References & Citations

[1]Riehl PS, et al. Antibody-Drug Conjugates of NLRP3 Agonists: How Overcoming Lysosomal Accumulation Necessitated Noncanonical Linker Attachments. J Med Chem. 2025 May 8;68 (9) :9799-9810.