CDK9 degrader-1
CDK9 degrader-1 (Compound AZ-9) is a selective CDK9 degrader (DC50: 0.4073 µM) . CDK9 degrader-1 recruits ATG101 to initiate the autophagy-lysosome pathway and forms autophagosomes by recruiting LC3, which then fuses with lysosomes to degrade CDK9 and its partner protein Cyclin T1 (DC50: 1.215 µM) . CDK9 degrader-1 induces caspase 3-mediated apoptosis. CDK9 degrader-1 has antitumor activity in a mouse HCT116 xenograft model[1].
Product Specifications
UNSPSC
12352005
Target
CDK
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
ClC1=C(C(NC2=CNN=C2C(NC3CCN(C(CCC(NC4=C(CCC5)C5=CC6=C4CCC6)=O)=O)CC3)=O)=O)C(Cl)=CC=C1
Molecular Formula
C32H34Cl2N6O4
Molecular Weight
637.56
References & Citations
[1]Zhong Y, et al. First ATG101-recruiting small molecule degrader for selective CDK9 degradation via autophagy–lysosome pathway[J]. Acta Pharmaceutica Sinica B, 2025.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK9
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
orb1562535-01 250 µL
Pneumococcal Type III Antigen, CRM197-Conjugate
Sign In for Pricing
View Details 
