CDK9 degrader-1

CDK9 degrader-1 (Compound AZ-9) is a selective CDK9 degrader (DC50: 0.4073 µM) . CDK9 degrader-1 recruits ATG101 to initiate the autophagy-lysosome pathway and forms autophagosomes by recruiting LC3, which then fuses with lysosomes to degrade CDK9 and its partner protein Cyclin T1 (DC50: 1.215 µM) . CDK9 degrader-1 induces caspase 3-mediated apoptosis. CDK9 degrader-1 has antitumor activity in a mouse HCT116 xenograft model[1].

Product Specifications

UNSPSC

12352005

Target

CDK

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

ClC1=C(C(NC2=CNN=C2C(NC3CCN(C(CCC(NC4=C(CCC5)C5=CC6=C4CCC6)=O)=O)CC3)=O)=O)C(Cl)=CC=C1

Molecular Formula

C32H34Cl2N6O4

Molecular Weight

637.56

References & Citations

[1]Zhong Y, et al. First ATG101-recruiting small molecule degrader for selective CDK9 degradation via autophagy–lysosome pathway[J]. Acta Pharmaceutica Sinica B, 2025.