PROTAC BRD4 Degrader-32
PROTAC BRD4 Degrader-32 (Compound 22) is a BRD4 PROTAC degrader (DC50: 0.20 nM) . PROTAC BRD4 Degrader-32 connects the BRD4-binding domain and CRBN-binding domain through a unique carbon-carbon linked linker to form a ternary complex, inducing ubiquitination of BRD4 for proteasomal degradation. PROTAC BRD4 Degrader-32 is promising for research of BRD4-related cancers (such as hematological malignancies) . (Pink: GSK1324726A (HY-13960) ; Black: linker (HY-176450) ; Blue: Lenalidomide-5-Br (HY-W072954) ) [1].
Product Specifications
UNSPSC
12352005
Target
Epigenetic Reader Domain; PROTACs
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
ClC1=CC=C(N[C@@H]2C[C@H](C)N(C(C)=O)C3=C2C=C(C4=CC=C(C(NCCCCC5=CC=C6C(CN(C(CCC(N7)=O)C7=O)C6=O)=C5)=O)C=C4)C=C3)C=C1
Molecular Formula
C42H42ClN5O5
Molecular Weight
732.27
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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