Mrgx2 antagonist-3
Mrgx2 antagonist-3 (Compound B-40) is a highly selective antagonist of MrgX2 receptor with an IC50 value of 0.042-2.5 nM. Mrgx2 antagonist-3 blocks downstream G protein signaling and β-Arrestin recruitment, thereby inhibiting MrgX2 receptor-mediated calcium influx and cellular degranulation. Mrgx2 antagonist-3 is promising for research of inflammation-related diseases and pruritus, such as chronic urticaria, allergic asthma[1].
Product Specifications
CAS Number
[2641397-91-1]
UNSPSC
12352005
Target
Mas-related G-protein-coupled Receptor (MRGPR)
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Purity
98.09
Solubility
DMSO : 10 mg/mL (ultrasonic; warming)
Smiles
O=C1C(CC)=C(C(C)C)N=C2NC3=CC(F)=C(C=C3N12)F
Molecular Formula
C15H15F2N3O
Molecular Weight
291.30
References & Citations
[1]Christa Müller, et al. MRGX Receptor Antagonists. US20210128561A1. 2021-05-06.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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