(S) -CDK2 degrader 6
(S) -CDK2 degrader 6 (Compound 8) is the S-enantiomer of CDK2 degrader 6 (HY-176444) . (S) -CDK2 degrader 6 is a selective CDK2 molecular glue degrader with a DC50 of 166.7 nM in 24 h. (S) -CDK2 degrader 6 can be used for breast cancer research[1].
Product Specifications
CAS Number
[3083777-51-6]
UNSPSC
12352005
Target
CDK; Molecular Glues
Related Pathways
Cell Cycle/DNA Damage; PROTAC
Field of Research
Cancer
Purity
99.69
Smiles
FC(F)(C12CC(C2)(C3=NN=C(N[C@@H]4[C@H](N(C5=CC(F)=C([C@H]6C(NC(CC6)=O)=O)C(F)=C5)C4)C)O3)C1)F
Molecular Formula
C23H22F5N5O3
Molecular Weight
511.44
References & Citations
[1]RITZÉN A, et al. Compounds that mediate protein degradation and methods of use thereof. WO2025090727A1. 2025-05-01.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS6186751-01 0.1 mL
MRRF (Mitochondrial Ribosome Recycling Factor, MRFF, MTRRF, RRF) (PE)
Ask
View Details 
MBS6186751-02 5x 0.1 mL
MRRF (Mitochondrial Ribosome Recycling Factor, MRFF, MTRRF, RRF) (PE)
Ask
View Details 