CDK2 degrader 6
CDK2 degrader 6 (compound 6) is an orally active and potent CDK2 molecular glue degrader with a DC50 of 46.5 nM. CDK2 degrader 6 can be used in the study of breast cancer[1].
Product Specifications
CAS Number
[3036606-92-2]
UNSPSC
12352005
Target
CDK; Molecular Glues
Related Pathways
Cell Cycle/DNA Damage; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Purity
99.81
Smiles
O=C(C(CC1)C2=C(F)C=C(N3C[C@H](NC4=NN=C(C56CC(C6)(C(F)(F)F)C5)O4)[C@H]3C)C=C2F)NC1=O
Molecular Formula
C23H22F5N5O3
Molecular Weight
511.44
References & Citations
[1]Andreas RITZÉN, et al. Compounds that mediate protein degradation and methods of use thereof. WO2025090727A1. 2025-05-01.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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