CDK2 degrader 6

CDK2 degrader 6 (compound 6) is an orally active and potent CDK2 molecular glue degrader with a DC50 of 46.5 nM. CDK2 degrader 6 can be used in the study of breast cancer[1].

Product Specifications

CAS Number

[3036606-92-2]

UNSPSC

12352005

Target

CDK; Molecular Glues

Related Pathways

Cell Cycle/DNA Damage; PROTAC

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Purity

99.81

Smiles

O=C(C(CC1)C2=C(F)C=C(N3C[C@H](NC4=NN=C(C56CC(C6)(C(F)(F)F)C5)O4)[C@H]3C)C=C2F)NC1=O

Molecular Formula

C23H22F5N5O3

Molecular Weight

511.44

References & Citations

[1]Andreas RITZÉN, et al. Compounds that mediate protein degradation and methods of use thereof. WO2025090727A1. 2025-05-01.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, stored under nitrogen, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

41509051 1.0 mL

RPL35AP3 Adenovirus (Human)

Ask

View Details

QP7811-ec-50ug 50ug

Recombinant Human Serine/ threonine-protein kinase NIM1 Protein, His-SUMO, E.coli-50ug

Ask

View Details

RC224827L4V 200 µL

EVA1C (NM_058187) Human Tagged ORF Clone Lentiviral Particle

Ask

View Details

NB110-85538AF647 0.1 mL

Mouse Monoclonal Mesothelin Antibody (MB-G10) [Alexa Fluor 647]

Ask

View Details

D8044-01 10 mg

7,9-Dimethoxycarbonyl-2-ethoxycarbonyl-5-methoxy-1H-pyrrolo-[2,3-f]quinoline

Ask

View Details