CDK2 degrader 6

CDK2 degrader 6 (compound 6) is an orally active and potent CDK2 molecular glue degrader with a DC50 of 46.5 nM. CDK2 degrader 6 can be used in the study of breast cancer[1].

Product Specifications

CAS Number

[3036606-92-2]

UNSPSC

12352005

Target

CDK; Molecular Glues

Related Pathways

Cell Cycle/DNA Damage; PROTAC

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Purity

99.81

Smiles

O=C(C(CC1)C2=C(F)C=C(N3C[C@H](NC4=NN=C(C56CC(C6)(C(F)(F)F)C5)O4)[C@H]3C)C=C2F)NC1=O

Molecular Formula

C23H22F5N5O3

Molecular Weight

511.44

References & Citations

[1]Andreas RITZÉN, et al. Compounds that mediate protein degradation and methods of use thereof. WO2025090727A1. 2025-05-01.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, stored under nitrogen, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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