AChE-IN-88

AChE-IN-88 (Compound 26) is a novel pyridazine derivative. AChE-IN-88 is an orally active multi-target ligand for Alzheimer's disease (AD) that inhibits both acetylcholinesterase (AChE) and amyloid β protein (Aβ) aggregation (pIC50: 7.16) [1].

Product Specifications

CAS Number

[2758789-03-4]

UNSPSC

12352005

Target

Amyloid-β; Cholinesterase (ChE)

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Smiles

FC1=CC(CN(CC)CCCCCCN2N=C(C3=CC(NC(C)=O)=CC=C3O)C=CC2=O)=CC=C1

Molecular Formula

C27H33FN4O3

Molecular Weight

480.57

References & Citations

[1]Aloui M, et al. In silico design of novel pyridazine derivatives as balanced multifunctional agents against Alzheimer's disease. Sci Rep. 2025 May 7;15 (1) :15910.