HsClpP activator-1
HsClpP activator-1 (compound 24) is a potent HsClpP activator with an EC50 of 0.22 μM. HsClpP activator-1 effectively inhibits cancer cell growth with IC50 values of 0.1-1 μM[1].
Product Specifications
CAS Number
[3087033-83-5]
UNSPSC
12352005
Target
ClpP
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C1N([C@H](CCN2N=C(C=C21)CC3=CC(F)=CC(F)=C3)CO)CC4=CC=C(C=C4)C(F)(F)F
Molecular Formula
C23H20F5N3O2
Molecular Weight
465.42
References & Citations
[1]Tang R, et al. Design, Synthesis, and Biological Evaluation of Novel Activators of Human Caseinolytic Protease P with a Pyrazololactam Scaffold. J Med Chem. 2025 May 22;68 (10) :9984-10007.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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