Subquinocin
Subquinocin is a CYLD inhibitor that inhibits USP family deubiquitinases (DUBs) . Subquinocin enhances the activation of NF-κB and IFN pathways by inhibiting CYLD. Subquinocin promotes RIG-I-mediated activation of IRF3 and/or IRF7 in the interferon pathway[1].
Product Specifications
UNSPSC
12352005
Target
Deubiquitinase; IFNAR; NF-κB
Related Pathways
Cell Cycle/DNA Damage; Immunology/Inflammation; NF-κB
Field of Research
Cancer
Purity
99.83
Smiles
O=C1N(CC(C)C)C=C(NC(NC(CCSC)C(OC)=O)=O)C2=C1C=CC=C2
Molecular Formula
C20H27N3O4S
Molecular Weight
405.51
References & Citations
[1]Yamanaka S, et al. Subquinocin, a small molecule inhibitor of CYLD and USP-family deubiquitinating enzymes, promotes NF-κB signaling. Biochem Biophys Res Commun. 2020 Mar 26;524 (1) :1-7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 4
Available Sizes
Curated Selection
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