PROTAC PI3K/110β degrader-1
PROTAC PI3K/110β degrader-1 (J-9) is a PROTAC based PI3K/110β degrader (Red: PI3K/110β inhibitor , black: linker, Blue: E3 ligase ligand).
Product Specifications
CAS Number
3070438-85-3
UNSPSC
12352005
Target
PI3K; PROTACs
Related Pathways
PI3K/Akt/mTOR; PROTAC
Field of Research
Cancer
Smiles
O=C(NCC1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@@H](NC(CCOCCOCCNC(C4=CC=CC=C4NC(C)C5=CC(C)=CN6C5=NC(N7CCOCC7)=CC6=O)=O)=O)C(C)(C)C)=O
Molecular Formula
C51H65N9O9S
Molecular Weight
980.18
References & Citations
[1]Cen J, et al. Double Swords in One: Novel Selective PI3K/110β PROTAC Degraders for the Treatment of Multidrug-Resistant Cancer by Activating ERS and Inhibiting P-gp. J Med Chem. 2025 May 8;68 (9) :9446-9464.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
TP310245M 100 µg
Macrophage Inflammatory Protein 4 (CCL18) (NM_002988) Human Recombinant Protein
Sign In for Pricing
View Details