PROTAC PI3K/110β degrader-1
PROTAC PI3K/110β degrader-1 (J-9) is a PROTAC based PI3K/110β degrader (Red: PI3K/110β inhibitor , black: linker, Blue: E3 ligase ligand).
Product Specifications
CAS Number
3070438-85-3
UNSPSC
12352005
Target
PI3K; PROTACs
Related Pathways
PI3K/Akt/mTOR; PROTAC
Field of Research
Cancer
Smiles
O=C(NCC1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@@H](NC(CCOCCOCCNC(C4=CC=CC=C4NC(C)C5=CC(C)=CN6C5=NC(N7CCOCC7)=CC6=O)=O)=O)C(C)(C)C)=O
Molecular Formula
C51H65N9O9S
Molecular Weight
980.18
References & Citations
[1]Cen J, et al. Double Swords in One: Novel Selective PI3K/110β PROTAC Degraders for the Treatment of Multidrug-Resistant Cancer by Activating ERS and Inhibiting P-gp. J Med Chem. 2025 May 8;68 (9) :9446-9464.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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