PROTAC PI3K/110β degrader-1

PROTAC PI3K/110β degrader-1 (J-9) is a PROTAC based PI3K/110β degrader (Red: PI3K/110β inhibitor (HY-75124), black: linker, Blue: E3 ligase ligand) [1].

Product Specifications

CAS Number

[3070438-85-3]

UNSPSC

12352005

Target

PI3K; PROTACs

Related Pathways

PI3K/Akt/mTOR; PROTAC

Field of Research

Cancer

Smiles

O=C(NCC1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@@H](NC(CCOCCOCCNC(C4=CC=CC=C4NC(C)C5=CC(C)=CN6C5=NC(N7CCOCC7)=CC6=O)=O)=O)C(C)(C)C)=O

Molecular Formula

C51H65N9O9S

Molecular Weight

980.18

References & Citations

[1]Cen J, et al. Double Swords in One: Novel Selective PI3K/110β PROTAC Degraders for the Treatment of Multidrug-Resistant Cancer by Activating ERS and Inhibiting P-gp. J Med Chem. 2025 May 8;68 (9) :9446-9464.