VU6031545
VU6031545 is a potent mGlu 5 negative allosteric modulator with an IC50 of 15 nM. VU6031545 has excellent brain penetrant and oral bioavailability in rats[1].
Product Specifications
UNSPSC
12352005
Target
MGluR
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
O=C(NC1=NC(C)=CS1)C2=NC3=C(SC=C3)C(O[C@@H]4CCOC4)=C2
Molecular Formula
C16H15N3O3S2
Molecular Weight
361.44
References & Citations
[1]Crocker KE, et al. Discovery of Thieno[3,2-b]pyridine-5-carboxamide and 2,3-Difluorobenzamide Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5. ACS Med Chem Lett. 2025 Apr 22;16 (5) :865-874.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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