VU6031545

VU6031545 is a potent mGlu 5 negative allosteric modulator with an IC50 of 15 nM. VU6031545 has excellent brain penetrant and oral bioavailability in rats[1].

Product Specifications

UNSPSC

12352005

Target

MGluR

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Smiles

O=C(NC1=NC(C)=CS1)C2=NC3=C(SC=C3)C(O[C@@H]4CCOC4)=C2

Molecular Formula

C16H15N3O3S2

Molecular Weight

361.44

References & Citations

[1]Crocker KE, et al. Discovery of Thieno[3,2-b]pyridine-5-carboxamide and 2,3-Difluorobenzamide Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5. ACS Med Chem Lett. 2025 Apr 22;16 (5) :865-874.