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KRAS inhibitor-42

KRAS inhibitor-42 (compound 8) is a potent USP7 inhibitor. KRAS inhibitor-42 has high affinity against GDP-bound KRASG12D with a Ki of 2.7 μM[1].

Product Specifications

UNSPSC

12352005

Target

Ras

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway

Field of Research

Cancer

Smiles

OC1=C2C(S/C(N2CCCCCN([C@H]3CC[C@@H](N)CC3)C4=O)=N\S(C5=CN=C(N6CCC(N7CCC(N)CC7)CC6)C4=C5)(=O)=O)=C(Cl)C=C1

Molecular Formula

C34H47ClN8O4S2

Molecular Weight

731.37

References & Citations

[1]Waterson AG. Switching It up with New KRAS Inhibitors. J Med Chem. 2025 May 8;68 (9) :9126-9128.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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