KRAS inhibitor-42
KRAS inhibitor-42 (compound 8) is a potent USP7 inhibitor. KRAS inhibitor-42 has high affinity against GDP-bound KRASG12D with a Ki of 2.7 μM[1].
Product Specifications
UNSPSC
12352005
Target
Ras
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Field of Research
Cancer
Smiles
OC1=C2C(S/C(N2CCCCCN([C@H]3CC[C@@H](N)CC3)C4=O)=N\S(C5=CN=C(N6CCC(N7CCC(N)CC7)CC6)C4=C5)(=O)=O)=C(Cl)C=C1
Molecular Formula
C34H47ClN8O4S2
Molecular Weight
731.37
References & Citations
[1]Waterson AG. Switching It up with New KRAS Inhibitors. J Med Chem. 2025 May 8;68 (9) :9126-9128.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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