SDH-IN-27

SDH-IN-27 (Compound Q18) is a succinate dehydrogenase inhibitor (SDHI) (IC50: 9.7 mg/L) . SDH-IN-27 induces mycelial morphology changes and lipid peroxidation, and exhibits antifungal activity against C. camelliae (EC50: 6.0 mg/L) . SDH-IN-27 is an ergosterol biosynthesis inhibitor (EBI) that binds to the active site of CYP51, ultimately leading to cell death of pathogenic fungi[1].

Product Specifications

UNSPSC

12352005

Target

Fungal

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Smiles

CCC1=C(N2C(CCl)=C(C(NC3=NC=CC=N3)=O)C=N2)C=CC=C1

Molecular Formula

C17H16ClN5O

Molecular Weight

341.79

References & Citations

[1]Chen K, et al. Synthesis and Activity of Novel Pyrazole/Pyrrole Carboxamides Containing a Dinitrogen Six-Membered Heterocyclic as Succinate Dehydrogenase and Ergosterol Biosynthesis Inhibitors against Colletotrichum camelliae. J Agric Food Chem. 2025 May 7;73 (18) :10914-10922.