Phosphodiesterase-IN-4

Phosphodiesterase-IN-4 (compound 18) is a potent Tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitor. Phosphodiesterase-IN-4 inhibits colorectal cancer cells with an IC50 of 6.9 μM[1].

Product Specifications

UNSPSC

12352005

Target

Phosphodiesterase (PDE)

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

COC1=C(C=C2C(C(N(C3=C2C=CC4=C3C=C5OCOC5=C4)CCN(C)C)=O)=C1)OCCN6CCOCC6

Molecular Formula

C29H33N3O6

Molecular Weight

519.59

References & Citations

[1]Hu DX, et al. Synthesis of 5,9- and 5,8-Diaminoalkoxy Substituted Benzophenanthridinone Analogues as Tyrosyl-DNA Phosphodiesterase 1 Inhibitors and Their Radiosensitizing Activity. J Med Chem. 2025 May 8;68 (9) :9323-9340.