Phosphodiesterase-IN-4
Phosphodiesterase-IN-4 (compound 18) is a potent Tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitor. Phosphodiesterase-IN-4 inhibits colorectal cancer cells with an IC50 of 6.9 μM[1].
Product Specifications
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
COC1=C(C=C2C(C(N(C3=C2C=CC4=C3C=C5OCOC5=C4)CCN(C)C)=O)=C1)OCCN6CCOCC6
Molecular Formula
C29H33N3O6
Molecular Weight
519.59
References & Citations
[1]Hu DX, et al. Synthesis of 5,9- and 5,8-Diaminoalkoxy Substituted Benzophenanthridinone Analogues as Tyrosyl-DNA Phosphodiesterase 1 Inhibitors and Their Radiosensitizing Activity. J Med Chem. 2025 May 8;68 (9) :9323-9340.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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