ZYH-23
ZYH-23 is a potent necroptosis inhibitor. ZYH-23 blocks necroptosis by inhibiting RIPK1, RIPK3, and MLKL phosphorylation via HSP90 targeting[1].
Product Specifications
UNSPSC
12352005
Target
Necroptosis
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Smiles
O=C1C(C#N)=C[C@]2([C@]([H])(C1(C)C)CC[C@](C)(C2=CC3=O)[C@]4([C@]3([C@]5([C@@](C(NC6=CC=C(C=C6)C7=NN(C=C7)C)=O)(CC4)CCC(C)(C5)C)[H])[H])C)C
Molecular Formula
C41H50N4O3
Molecular Weight
646.86
References & Citations
[1]Zou Y, et al. Bardoxolone Derivatives as Novel Pseudo-Natural Necroptosis Inhibitors by Destabilizing HSP90 Client Proteins. J Med Chem. 2025 May 22;68 (10) :9906-9925.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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