DDO-6691
DDO-6691 is a heat shock protein 90 (HSP90) inhibitor. DDO-6691 has antiproliferative effects on a variety of tumor cells, with HCT-116 colon cancer cells being the most sensitive (IC50: 1.08 μM) . DDO-6691 exhibits potent tumor growth inhibition in the HCT-116 xenograft mouse model[1].
Product Specifications
CAS Number
2640292-52-8
UNSPSC
12352005
Target
HSP
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
O=S(/C=C/C1=CN(C2=CC=CC=C2)N=C1C3=CC=CN=C3)(C4=CC=CC=C4)=O
Molecular Formula
C22H17N3O2S
Molecular Weight
387.45
References & Citations
[1]Feng ZW, et al. Structural Optimization of Pyrazole Compounds as Hsp90 Regulators with Enhanced Antitumor Activity. J Med Chem. 2025 May 22;68 (10) :9886-9905.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HSP90
Frequently Asked Questions
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