DDO-6691

DDO-6691 is a heat shock protein 90 (HSP90) inhibitor. DDO-6691 has antiproliferative effects on a variety of tumor cells, with HCT-116 colon cancer cells being the most sensitive (IC50: 1.08 μM) . DDO-6691 exhibits potent tumor growth inhibition in the HCT-116 xenograft mouse model[1].

Product Specifications

CAS Number

[2640292-52-8]

UNSPSC

12352005

Target

HSP

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Field of Research

Cancer

Smiles

O=S(/C=C/C1=CN(C2=CC=CC=C2)N=C1C3=CC=CN=C3)(C4=CC=CC=C4)=O

Molecular Formula

C22H17N3O2S

Molecular Weight

387.45

References & Citations

[1]Feng ZW, et al. Structural Optimization of Pyrazole Compounds as Hsp90 Regulators with Enhanced Antitumor Activity. J Med Chem. 2025 May 22;68 (10) :9886-9905.