FPR1 antagonist 3

FPR1 antagonist 3 (compound 10) is a potent and selective FPR1 antagonist. FPR1 antagonist 3 inhibits superoxide anion generation and elastase release with IC50s of 0.33 and 0.84 μM, respectively[1].

Product Specifications

CAS Number

[3058943-53-3]

UNSPSC

12352005

Target

Formyl Peptide Receptor (FPR)

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

ClC1=CC(N2N(C3=CC=CC(Cl)=C3)C(C(C(NC4=NC=C([N+]([O-])=O)S4)=O)C2)=O)=CC=C1

Molecular Formula

C19H13Cl2N5O4S

Molecular Weight

478.31

References & Citations

[1]Abdel-Halim, M., et al. Targeting Neutrophil-Mediated Inflammation: Identification of Pyrazolidinone Carboxamide Derivatives as Potent Selective Inhibitors of Formyl Peptide Receptor 1 (FPR1) -Activated Neutrophils. ACS Pharmacology & Translational Science.