FPR1 antagonist 3
FPR1 antagonist 3 (compound 10) is a potent and selective FPR1 antagonist. FPR1 antagonist 3 inhibits superoxide anion generation and elastase release with IC50s of 0.33 and 0.84 μM, respectively[1].
Product Specifications
CAS Number
3058943-53-3
UNSPSC
12352005
Target
Formyl Peptide Receptor (FPR)
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
ClC1=CC(N2N(C3=CC=CC(Cl)=C3)C(C(C(NC4=NC=C([N+]([O-])=O)S4)=O)C2)=O)=CC=C1
Molecular Formula
C19H13Cl2N5O4S
Molecular Weight
478.31
References & Citations
[1]Abdel-Halim, M., et al. Targeting Neutrophil-Mediated Inflammation: Identification of Pyrazolidinone Carboxamide Derivatives as Potent Selective Inhibitors of Formyl Peptide Receptor 1 (FPR1) -Activated Neutrophils. ACS Pharmacology & Translational Science.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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