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Dyrk1A-IN-13

Dyrk1A-IN-13 (Compound 1) is a DYRK1A inhibitor (IC50: 41 nM) . Dyrk1A-IN-13 reduces LPS-induced NO production and has antioxidant and anti-inflammatory activities. Dyrk1A-IN-13 can be used in the research of Alzheimer's disease, cancer and diabetes[1].

Product Specifications

UNSPSC

12352005

Target

DYRK; NO Synthase

Related Pathways

Immunology/Inflammation; Protein Tyrosine Kinase/RTK

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology; Neurological Disease

Smiles

CN(CC1)CCC1N(N=C2)C=C2C3=CC(C(C4=CC=CC(F)=C4)=CN5)=C5N=C3

Molecular Formula

C22H22FN5

Molecular Weight

375.44

References & Citations

[1]García EG, et al. AI-Driven De Novo Design and Development of Nontoxic DYRK1A Inhibitors. J Med Chem. 2025 May 22;68 (10) :10346-10364.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

DYRK1

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