Dyrk1A-IN-13
Dyrk1A-IN-13 (Compound 1) is a DYRK1A inhibitor (IC50: 41 nM) . Dyrk1A-IN-13 reduces LPS-induced NO production and has antioxidant and anti-inflammatory activities. Dyrk1A-IN-13 can be used in the research of Alzheimer's disease, cancer and diabetes[1].
Product Specifications
UNSPSC
12352005
Target
DYRK; NO Synthase
Related Pathways
Immunology/Inflammation; Protein Tyrosine Kinase/RTK
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Metabolic Disease; Inflammation/Immunology; Neurological Disease
Smiles
CN(CC1)CCC1N(N=C2)C=C2C3=CC(C(C4=CC=CC(F)=C4)=CN5)=C5N=C3
Molecular Formula
C22H22FN5
Molecular Weight
375.44
References & Citations
[1]García EG, et al. AI-Driven De Novo Design and Development of Nontoxic DYRK1A Inhibitors. J Med Chem. 2025 May 22;68 (10) :10346-10364.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DYRK1
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