Ad-JQ1
Ad-JQ1 (Compound 16) is an Target Protein Ligand-Linker Conjugate that incorporates a ligand for BRD4 and a PROTAC linker (HY-176390), which recruits E3 ligases. Ad-JQ1 can be used for synthesis of PROTAC β-NF-JQ1 (HY-130256).
Product Specifications
CAS Number
2497485-14-8
UNSPSC
12352005
Target
Epigenetic Reader Domain; Target Protein Ligand-Linker Conjugates
Related Pathways
Epigenetics; PROTAC
Field of Research
Cancer
Smiles
O=C(NCCOCCOCCNC(C[C@H]1C2=NN=C(C)N2C3=C(C(C)=C(C)S3)C(C4=CC=C(Cl)C=C4)=N1)=O)CC5(C[C@@H](C6)C7)C[C@@H]7C[C@@H]6C5
Molecular Formula
C37H47ClN6O4S
Molecular Weight
707.32
References & Citations
[1]Shoda T, et al. Targeted Protein Degradation by Chimeric Compounds using Hydrophobic E3 Ligands and Adamantane Moiety. Pharmaceuticals (Basel) . 2020 Feb 25;13 (3) :34.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRD4
Frequently Asked Questions
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