Ad-JQ1

Ad-JQ1 (Compound 16) is an Target Protein Ligand-Linker Conjugate that incorporates a ligand for BRD4 (HY-78695) and a PROTAC linker (HY-176390), which recruits E3 ligases. Ad-JQ1 can be used for synthesis of PROTAC β-NF-JQ1 (HY-130256) [1].

Product Specifications

CAS Number

[2497485-14-8]

UNSPSC

12352005

Target

Epigenetic Reader Domain; Target Protein Ligand-Linker Conjugates

Related Pathways

Epigenetics; PROTAC

Field of Research

Cancer

Smiles

O=C(NCCOCCOCCNC(C[C@H]1C2=NN=C(C)N2C3=C(C(C)=C(C)S3)C(C4=CC=C(Cl)C=C4)=N1)=O)CC5(C[C@@H](C6)C7)C[C@@H]7C[C@@H]6C5

Molecular Formula

C37H47ClN6O4S

Molecular Weight

707.32

References & Citations

[1]Shoda T, et al. Targeted Protein Degradation by Chimeric Compounds using Hydrophobic E3 Ligands and Adamantane Moiety. Pharmaceuticals (Basel) . 2020 Feb 25;13 (3) :34.