PROTAC BRD4 ligand-1-NH-PEG-phenol-PEG-COOtBu
PROTAC BRD4 ligand-1-NH-PEG-phenol-PEG-COOtBu is an Target Protein Ligand-Linker Conjugate that incorporates a ligand for BRD4 and a PROTAC linker. PROTAC BRD4 ligand-1-NH-PEG-phenol-PEG-COOtBu can be used for synthesis of PROTAC BRD4 Degrader-14 (HY-138637) [1].
Product Specifications
CAS Number
[2973054-19-0]
UNSPSC
12352005
Target
Epigenetic Reader Domain; Target Protein Ligand-Linker Conjugates
Related Pathways
Epigenetics; PROTAC
Field of Research
Cancer
Smiles
O=C(COCCC1=CC(OCCNC(C2=CC3=C(C4=CN(C)C(C5=C4C(CN3C6=NC=C(C=C6F)F)=CN5)=O)C=C2CS(=O)(C)=O)=O)=CC(O)=C1)OC(C)(C)C
Molecular Formula
C39H41F2N5O9S
Molecular Weight
793.83
References & Citations
[1]Dragovich PS, et al. Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy. J Med Chem. 2021 Mar 11;64 (5) :2576-2607.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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