Palbociclib-C4-Boc

Palbociclib-C4-Boc is a Target Protein Ligand-Linker Conjugate that incorporates a ligand for CDK4/6 Palbociclib and a PROTAC linker (HY-W007803), which recruits E3 ligases. Palbociclib-C4-Boc can be used for synthesis of PROTAC BSJ-03-204 (HY-136250).

Product Specifications

CAS Number

2139329-48-7

UNSPSC

12352005

Target

CDK; Target Protein Ligand-Linker Conjugates

Related Pathways

Cell Cycle/DNA Damage; PROTAC

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

O=C1N(C2CCCC2)C3=NC(NC4=CC=C(N(CC5)CCN5CCCCNC(OC(C)(C)C)=O)C=N4)=NC=C3C(C)=C1C(C)=O

Molecular Formula

C33H46N8O4

Molecular Weight

618.77

References & Citations

[1]Jiang B, et al. Development of Dual and Selective Degraders of Cyclin-Dependent Kinases 4 and 6. Angew Chem Int Ed Engl. 2019 May 6;58 (19) :6321-6326.