Adavosertib-C3-NH-Boc

Adavosertib-C3-NH-Boc is a Target Protein Ligand-Linker Conjugate that incorporates a ligand for Wee1 (HY-10993) and a PROTAC linker (HY-W011561), which recruits E3 ligases. Adavosertib-C3-NH-Boc can be used for synthesis of PROTAC Pomalidomide-C3-adavosertib (HY-133618) [1].

Product Specifications

CAS Number

[2113725-19-0]

UNSPSC

12352005

Target

Target Protein Ligand-Linker Conjugates; Wee1

Related Pathways

Cell Cycle/DNA Damage; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C1N(CC=C)N(C2=NC(C(O)(C)C)=CC=C2)C3=NC(NC4=CC=C(N5CCN(CCCNC(OC(C)(C)C)=O)CC5)C=C4)=NC=C31

Molecular Formula

C34H45N9O4

Molecular Weight

643.78

References & Citations

[1]Nathanael S. Gray, et al. Degraders of wee1 kinase. WO2020069105A1. 2020-04-02.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

NBP2-54488R 100 µL

Mouse Monoclonal Spectrin beta 3 Antibody (SPTBN2/1582) [DyLight 550]

Ask

View Details

HC969014-01 50 µg

Anti-Human SLITRK5 Polyclonal Antibody

Ask

View Details

HC969014-02 100 µg

Anti-Human SLITRK5 Polyclonal Antibody

Ask

View Details

abx938354-01 15 nmol

Mouse TSPAN9 siRNA

Ask

View Details

abx938354-02 30 nmol

Mouse TSPAN9 siRNA

Ask

View Details

50323164 1.0 µg

Wdr35 AAV siRNA Pooled Vector

Ask

View Details