Adavosertib-C3-NH-Boc
Adavosertib-C3-NH-Boc is a Target Protein Ligand-Linker Conjugate that incorporates a ligand for Wee1 (HY-10993) and a PROTAC linker (HY-W011561), which recruits E3 ligases. Adavosertib-C3-NH-Boc can be used for synthesis of PROTAC Pomalidomide-C3-adavosertib (HY-133618) [1].
Product Specifications
CAS Number
[2113725-19-0]
UNSPSC
12352005
Target
Target Protein Ligand-Linker Conjugates; Wee1
Related Pathways
Cell Cycle/DNA Damage; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C1N(CC=C)N(C2=NC(C(O)(C)C)=CC=C2)C3=NC(NC4=CC=C(N5CCN(CCCNC(OC(C)(C)C)=O)CC5)C=C4)=NC=C31
Molecular Formula
C34H45N9O4
Molecular Weight
643.78
References & Citations
[1]Nathanael S. Gray, et al. Degraders of wee1 kinase. WO2020069105A1. 2020-04-02.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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