(S, S, S) -VH032-cyclopropane-F-C4-aldehyde
(S, S, S) -VH032-cyclopropane-F-C4-aldehyde is an E3 ligase ligand-linker conjugate used in the synthesis of PROTAC cis-VZ185 (HY-114322A) [1].
Product Specifications
CAS Number
[2306193-97-3]
UNSPSC
12352005
Target
E3 Ligase Ligand-Linker Conjugates
Related Pathways
PROTAC
Field of Research
Cancer
Smiles
[H]C(CCCCOC1=C(CNC([C@H]2N(C([C@@H](NC(C3(F)CC3)=O)C(C)(C)C)=O)C[C@@H](O)C2)=O)C=CC(C4=C(N=CS4)C)=C1)=O
Molecular Formula
C31H41FN4O6S
Molecular Weight
616.74
References & Citations
[1]Iterative design and optimization of initially inactive proteolysis targeting chimeras (PROTACs) identify VZ185 as a potent, fast, and selective von Hippel–Lindau (VHL) .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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