Nebivolol O-β-D-glucuronide

Nebivolol O-β-D-glucuronide is a derivative of Nebivolol (HY-B0203) . Nebivolol is an orally active beta receptor blocker and has the high beta (1) -receptor affinity. Nebivolol has direct vasodilator properties and adrenergic blocking characteristics. Nebivolol can be used for the research of kinds of diseases such as hypertension, coronary artery disease, congestive heart failure and ischemic heart disease[1][2][3].

Product Specifications

UNSPSC

12352005

Target

Adrenergic Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology; Cardiovascular Disease

Smiles

FC1=CC=C2C(CCC([H])(O2)C(CNCC(C3(CCC4=C(O3)C=CC(F)=C4)[H])O)O[C@]5([C@@H]([C@H]([C@@H]([C@H](O5)C(O)=O)O)O)O)[H])=C1

Molecular Formula

C28H33F2NO10

Molecular Weight

581.56

References & Citations

[1]Vieira CP, et al. An indirect stereoselective analysis of nebivolol glucuronides in plasma by LC-MS/MS: Application to clinical pharmacokinetics. J Pharm Biomed Anal. 2017 Sep 10;144:25-30. |[2]Thomas Münzel, et al. Nebivolol: the somewhat-different beta-adrenergic receptor blocker. J Am Coll Cardiol. 2009 Oct 13;54 (16) :1491-9.|[3]Brehm BR, et al. Effects of nebivolol on proliferation and apoptosis of human coronary artery smooth muscle and endothelial cells. Cardiovasc Res. 2001 Feb 1;49 (2) :430-9