(S, S, S) -VH032-cyclopropane-F
(S, S, S) -VH032-cyclopropane-F is a ligand for E3 ubiquitin ligases. (S, S, S) -VH032-cyclopropane-F can be linked to target protein ligands via a linker to form the PROTAC cis-VZ185 (HY-114322A) [1].
Product Specifications
CAS Number
[2306193-95-1]
UNSPSC
12352100
Target
Ligands for E3 Ligase
Related Pathways
PROTAC
Field of Research
Cancer
Smiles
OC1=C(CNC([C@H]2N(C([C@@H](NC(C3(F)CC3)=O)C(C)(C)C)=O)C[C@@H](O)C2)=O)C=CC(C4=C(N=CS4)C)=C1
Molecular Formula
C26H33FN4O5S
Molecular Weight
532.63
References & Citations
[1]Zoppi V, et al. Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel-Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7. J Med Chem. 2019 Jan 24;62 (2) :699-726.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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