ARN25657
ARN25657 is a dual-acting D3R/GSK-3β modulator. ARN25657 has both partial D3R agonist activity (EC50 = 15.2 nM, Ki =1.5 nM) and potent GSK-3β inhibitor activity (IC50 = 19.3 nM) . ARN25657 exhibits excellent GSK-3β selectivity over FYN, PKA, and CDK5/p35. ARN25657 inhibits P-glycoprotein (P-gP) -mediated acetoxymethyl calcein efflux and improves in vitro ADME properties while maintaining a balanced dual-target profile. ARN25657 is useful for studying bipolar disorder and related neuropsychiatric disorders[1].
Product Specifications
UNSPSC
12352005
Target
Dopamine Receptor; GSK-3; P-glycoprotein; PKA
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling; PI3K/Akt/mTOR; Stem Cell/Wnt; TGF-beta/Smad
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
O=C(N(C1=CC(C2=CC=CN=C2)=CC=C1N3)C3=O)NCCCN4CCN(C5=CC=CC=C5)CC4
Molecular Formula
C26H28N6O2
Molecular Weight
456.54
References & Citations
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-176287/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
D3 Receptor; GSK-3β
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