PI3Kα-IN-26

PI3Kα-IN-26 (Compound 11e) is a PI3Kα inhibitor with an IC50 of 75.31 nM. PI3Kα-IN-26 has a broad-spectrum anticancer activity, such as leukemia, colon and breast cancer, without significant cytotoxic effect on the normal Vero cells (mean IC50s of 2.74, 3.50, 3.34 and 85.29 μM, respectively) [1].

Product Specifications

UNSPSC

12352005

Target

CDK; PI3K

Related Pathways

Cell Cycle/DNA Damage; PI3K/Akt/mTOR

Field of Research

Cancer

Smiles

O=C1/C(S/C(N1C2=CC=CC=C2)=N\CCNS(=O)(C3=CC=CC=C3)=O)=C\C4=CC=C(C=C4)Cl

Molecular Formula

C24H20ClN3O3S2

Molecular Weight

498.02

References & Citations

[1]Mohamed AR, et al. Integrated structure- and ligand-based design, synthesis, and biological evaluation of potent thiazole-based multi-kinase PI3Kα and CDK2/8 inhibitors as anticancer agents. Eur J Med Chem. 2025 Oct 15;296:117902.