SARS-CoV-2-IN-115
SARS-CoV-2-IN-115 (Compound 3e) is a SARS-CoV-2 inhibitor. SARS-CoV-2-IN-115 has potent antiviral activity against SARS-CoV-2 in infected Calu-3 cells (EC50: 1.7 μM) . SARS-CoV-2-IN-115 effectively inhibits the activity of human dihydroorotate dehydrogenase (HsDHODH) (IC50: 1.5 μM) . SARS-CoV-2-IN-115 preserves immune response without antiproliferative effects on CD4 T cells [1].
Product Specifications
CAS Number
2557232-80-9
UNSPSC
12352005
Target
Dihydroorotate Dehydrogenase; DNA/RNA Synthesis; SARS-CoV
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Infection
Smiles
CC(NC1=CC=C(C=C1)C#CC2=CC(N)=CC=C2)=O
Molecular Formula
C16H14N2O
Molecular Weight
250.30
References & Citations
[1]Vaidergorn MM, et al. Targeting dihydroorotate dehydrogenase (DHODH) for host-directed therapy: Discovery of a novel alkyne-based scaffold inhibitor effective against SARS-CoV-2. Eur J Med Chem. 2025 Jun 21;297:117876.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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