FASN/SCD-IN-1
FASN/SCD-IN-1 is a Silybin derivative, an orally active inhibitor of Fatty Acid Synthase (FASN) /Stearoyl-CoA Desaturase (SCD). FASN/SCD-IN-1 has shown in vitro activity in inhibiting lipid deposition, reducing FASN and SCD transcriptional levels, and exhibiting antioxidant, anti-inflammatory, and anti-fibrotic activities. FASN/SCD-IN-1 has demonstrated significant hepatoprotective effects in a rat model of acute liver injury. FASN/SCD-IN-1 ameliorates the pathological features of MASH liver, including steatosis, inflammation, and fibrosis in a mouse model of myeloproliferative steatohepatitis (MASH). FASN/SCD-IN-1 can be used to study MASH[1].
Product Specifications
UNSPSC
12352005
Target
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology
Smiles
OC1=C2C([C@@H]([C@H](OC2=CC(O)=C1)C3=CC4=C(C=C3)OC(CS)[C@H](C5=CC=C(C(OC)=C5)O)O4)O)=O
Molecular Formula
C25H22O9S
Molecular Weight
498.50
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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