RORγt inverse agonist 35
RORγt inverse agonist 35 (Compound 22) is a RORγt inverse agonist with an IC50 of 1.51 μM. RORγt inverse agonist 35 significantly inhibits Th17 differentiation and proinflammatory properties in human CD4+ T cells. RORγt inverse agonist 35 can be used for research of Th17-driven autoimmune diseases, such as psoriasis, multiple sclerosis, and inflammatory bowel disease (IBD) [1].
Product Specifications
UNSPSC
12352005
Target
Interleukin Related; ROR
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Field of Research
Inflammation/Immunology
Smiles
CC(S(=O)(C1=CC=C(C=C1)C2=CN3C=C(C=C3C=C2)C(NCC4=CC=C(C=C4)F)=O)=O)C
Molecular Formula
C25H23FN2O3S
Molecular Weight
450.53
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-17; IL-22; RORγ
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