MAO-B-IN-45

MAO-B-IN-45 is a dual inhibitor of ferroptosis and MAO-B. MAO-B-IN-45 shows selectivity towards MAO-B with an IC50 of 87.47 nM and selectivity exceeding 229-fold for MAO-B over MAO-A. MAO-B-IN-45 has excellent antiferroptosis activity through modulation of the iron metabolic pathway and GSH-GPX4 axis in vitro. MAO-B-IN-45 improves cognitive and behavioral impairments in 3xTg (APP/Tau/Ps1) AD mouse and significantly reduced the levels of ferritin heavy chain 1 (FTH1), APP, and Tau phosphorylation (p-Tau) proteins in the brain[1].

Product Specifications

CAS Number

[3069915-36-9]

UNSPSC

12352005

Target

Amyloid-β; Ferroptosis; Glutathione Peroxidase; Monoamine Oxidase; Reactive Oxygen Species (ROS) ; Tau Protein

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Smiles

CN1C(C(O)=CC2=CC=C(C=C21)OCC3=CC=C(C=C3)Cl)=O

Molecular Formula

C17H14ClNO3

Molecular Weight

315.75

References & Citations

[1]Lv Y, et al. 3-Hydroxyquinolin-2-Ones Act as Dual Inhibitors of Ferroptosis and Monoamine Oxidase B: Reducing Alzheimer's Disease-Related Amyloid Precursor Protein and Hyperphosphorylated Tau In Vivo. J Med Chem. 2025 Jun 21.