ESC1002755
ESC1002755 is a 17β-HSD10 inhibitor with an IC50 of 19 nM. ESC1002755 has significant enzyme specificity with non-/uncompetitive inhibition against the cofactor NADH. ESC1002755 shows minimal cytotoxicity towards the HEK293 at 50 μM. ESC1002755 is promising for Alzheimer’s disease and hormone-dependent cancers (such as prostate, bone and colorectal cancer) research[1].
Product Specifications
CAS Number
2915567-21-2
UNSPSC
12352005
Target
17β-HSD
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer; Neurological Disease
Smiles
O=C(N1CCC[C@H]1C2=C(C=CC=C2)C3=CC(O)=CC=C3)C4=C(C=CS4)Cl
Molecular Formula
C21H18ClNO2S
Molecular Weight
383.89
References & Citations
[1]Aitken L, et al. High-Throughput Screening of Potent Drug-like Molecules Targeting 17β-HSD10 for the Treatment of Alzheimer's Disease and Cancer. ACS Chem Biol. 2025 Jun 18.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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