SGC-NSP2hel-1
SGC-NSP2hel-1 (RA-0188293), a chemical probe, is a potent, specific and orally active nsP2 inhibitor. SGC-NSP2hel-1 has broad spectrum activity against multiple alphaviruses of the nsP2 helicase with a CC50 > 250 μM. SGC-NSP2hel-1 (RA-0188293) shows selectivity index > 4000 against human RNA helicases. SGC-NSP2hel-1 reduces virus replication and limited virus-induced pathology by forming a stable complex with nsP2 and ATP in a preclinical small animal model of CHIKV disease[1].
Product Specifications
Product Name Alternative
RA-0188293; RA-NSP2-1
UNSPSC
12352005
Target
Flavivirus; Virus Protease
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Smiles
O=C(C1(CCCC1)C2=CC=CC=C2)N(CC3)CCC43OCC[C@@H](CN5CCCCS5(=O)=O)C4
Molecular Formula
C26H38N2O4S
Molecular Weight
474.66
References & Citations
[1]John D. Sears, et al. Identification of a Broadly Acting Inhibitor of the Alphavirus Non-Structural Protein 2 Helicase. bioRxiv.June 04,2025.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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