STING agonist-44
STING agonist-44 (Compound 4) is a potent and selective STING agonist with an EC50 value of 5.68 for IRF induction in THP1 cells and 2.212 μM in RAW cells. STING agonist-44 activates the STING pathway, inducing the production of type I interferons and pro-inflammatory cytokines (e.g., CXCL10, TNFα) . STING agonist-44 is promising for research of cancers[1].
Product Specifications
UNSPSC
12352005
Target
STING
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O[C@H]1[C@@H](OP(SC[C@]23[C@@H](O4)[C@@H](OC3)[C@H](N5C=NC6=C5N=CN=C6N)O2)(O)=O)[C@H](N(C=N7)C8=C7C(NC(N)=N8)=O)O[C@@H]1COP4(O)=O
Molecular Formula
C21H24N10O12P2S
Molecular Weight
702.49
References & Citations
[1]Yeboah S K, et al. 5′-Phosphorothioester Linked Cyclic Dinucleotides, Endo-S-CDNs, Displaying Impressive Antitumor Activities In Vivo when Dosed Subcutaneously[J]. ACS Bio & Med Chem Au, 2025.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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