TBK1 degrader-4
TBK1 degrader-4 (Compound 30) is a molecular glue degrader targeting TBK1. TBK1 degrader-4 effectively inhibits cyst growth, alleviates inflammation, and reduces the levels of pro-inflammatory factors such as Ccl2, IFNβ, and IL-6. TBK1 degrader-4 is promising for research of autosomal dominant polycystic kidney disease (ADPKD) [1].
Product Specifications
UNSPSC
12352005
Target
CCR; Interleukin Related; Molecular Glues
Related Pathways
GPCR/G Protein; Immunology/Inflammation; PROTAC
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
O=C(N1CCN(CC2CCN(CC3=CC(NC4=NC=C(C=CN5CCCNC(C6CCC6)=O)C5=N4)=CC=C3)CC2)CC1)/C=C/C(C7=CC=C(OC)C=C7)=O
Molecular Formula
C42H52N8O4
Molecular Weight
732.91
References & Citations
[1]Guo J, et al. Discovery of TBK1Molecular Glue Degraders as a Potential Strategy for the Treatment of Autosomal Dominant Polycystic Kidney Disease (ADPKD) . J Med Chem. 2025 Jun 26;68 (12) :12862-12880.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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