TBK1 degrader-4

TBK1 degrader-4 (Compound 30) is a molecular glue degrader targeting TBK1. TBK1 degrader-4 effectively inhibits cyst growth, alleviates inflammation, and reduces the levels of pro-inflammatory factors such as Ccl2, IFNβ, and IL-6. TBK1 degrader-4 is promising for research of autosomal dominant polycystic kidney disease (ADPKD) [1].

Product Specifications

UNSPSC

12352005

Target

CCR; Interleukin Related; Molecular Glues

Related Pathways

GPCR/G Protein; Immunology/Inflammation; PROTAC

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

O=C(N1CCN(CC2CCN(CC3=CC(NC4=NC=C(C=CN5CCCNC(C6CCC6)=O)C5=N4)=CC=C3)CC2)CC1)/C=C/C(C7=CC=C(OC)C=C7)=O

Molecular Formula

C42H52N8O4

Molecular Weight

732.91

References & Citations

[1]Guo J, et al. Discovery of TBK1Molecular Glue Degraders as a Potential Strategy for the Treatment of Autosomal Dominant Polycystic Kidney Disease (ADPKD) . J Med Chem. 2025 Jun 26;68 (12) :12862-12880.