CALR ligand 1
CALR ligand 1 (Compound 2a) is a calreticulin (CALR) ligand. CALR ligand 1 shows antitumor activity against triple-negative breast cancer (TNBC) cells (IC50=0.1 μM) . CALR ligand 1 induces intracellular calcium overloading and triggers apoptosis in TNBC cells. CALR ligand 1 is promising for research of TNBC [1].
Product Specifications
CAS Number
3055854-78-6
UNSPSC
12352005
Target
Apoptosis
Related Pathways
Apoptosis
Field of Research
Cancer
Smiles
O=S(C1=CC=C(C2=CN=C3C(C(NC(CCl)=O)=NN3)=C2)C=C1)(C(C)C)=O
Molecular Formula
C17H17ClN4O3S
Molecular Weight
392.86
References & Citations
[1]Lu J, et al. Design, Synthesis, and Evaluation of Pyrazolopyridine Derivatives as Novel Calreticulin (CALR) Ligands That Inhibit Triple-Negative Breast Cancer (TNBC) via Inducing Calcium Overloading. J Med Chem. 2025 Jun 12;68 (11) :11419-11436.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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